| Title: | ProKryos: protein crystallization for the benefit of people |
| Material Type: | ISU Team Project report |
| Publisher: | Illkirch-Graffenstaden (France) : International Space University, 2022 |
| Format: | 1 electronic resource (xii, 112 p.) / col. ill. |
| Bibliography note: | Includes bibliographical references |
| Languages: | English |
| Subjects: | Manned space flight ; Pharmacology ; Space medicine |
| Description: | Our mission is to develop an orbital pharmaceutical factory, ProKryos-Panacea, with an initial focus on the mass production of crystalline protein drugs such as monoclonal antibodies (mAbs). Protein drugs can be used in the treatment of cancer, auto-immune diseases and other health related issues such a migraines and anaemia. The benefits of a microgravity environment for the production of protein crystals have been well documented. However, in the last ten years access to space has become cheaper and more readily available, making now the opportunity for such a business venture. This report investigates the current state of space pharmaceutical manufacturing, setting the scene for our business proposition. We then define a timeline of distinct phases required to make ProKryos-Panacea a reality, covering the scientific, engineering, business, and regulatory verticals to this grand aim. Our report culminates in a detailed description of our demonstrator mission, ProKryos-I, testing our novel hardware for the mass production of protein crystals suitable for pharmaceutical use. This report and the suggestions within it aim to unleash the potential of pharmaceutical manufacturing by paving a viable and life-changing pathway into space. |
| Contents note: | 1.Introduction 2. Crystallization of proteins for the treatment of disease 3. ProKryos timeline 4. Demonstrator mission, ProKryos-I 5. Conclusion |
| ISU program : | Space Studies Program |
| Format : | Open Access |
| Permalink: | https://isulibrary.isunet.edu/index.php?lvl=notice_display&id=11571 |
Read online (2)
 2022_ProKryos_Executive summary (17.8MB) Adobe Acrobat PDF | 2022_ProKryos_Full report (6.20MB) Adobe Acrobat PDF |
